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Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. Nat Med 28, 20832091 (2022)

You can live without a pancreas, but youd struggle with severe diabetes and would constantly have to manage your blood sugar

Since the two different pharmacological activities of the peptide antibody fusion molecule cannot be titrated separately, precise adjustment of the potency at GLP-1R was required to achieve effective and safe GLP-1 activity at doses likely able to suppress PCSK9

On top of that, exercise on its own can improve cardiovascular and bone health, so its never an either-or decision, Kushner says

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